Design and characterization of fast dissolving buccal film of imipramine HCL

In depressed individuals, Imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. hydrochloride having variable bioavailability i.e. ranging from 29-77% due to first pass metabolism, peak plasma concentration is usually attained 2-6 hours. Absorption unaffected by food. It freely soluble in water. The objective this research work improve the drug fast onset action decrease depressant activity. Buccal HCL only for reason can be administered into mucosa using mucoadhesive film. made release directly enter blood circulation through increase bioavailability. Fast dissolving films were prepared solvent casting method various polymers like hydroxyl propyl methyl cellulose E15, PVP, PVA sodium saccharin, plasticizer vanillin as flavouring agent. Dissolution profile studied USP dissolution apparatus type 1 pH 6.8 simulated saliva. influence polymer was studied. formulation optimized basis evaluation parameters content vitro release. Formulation F3 successfully within 8 minutes. IR Spectra revealed absence interaction between selected polymer, results stability studies per ICH guide lines indicated that stable.